Journal
SCIENCE
Volume 296, Issue 5574, Pages 1855-1857Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1069871
Keywords
-
Categories
Funding
- NICHD NIH HHS [HD 17608] Funding Source: Medline
- NIGMS NIH HHS [1R01 GM64428-01, R01 GM064428] Funding Source: Medline
Ask authors/readers for more resources
How stem cells are recruited to and maintained in their niches is crucial to understanding their regulation and use in regenerative medicine. Here, we demonstrate that DE-cadherin-mediated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosophila ovary. Two major components of this adhesion process, DE-cadherin and Armadillo/beta-catenin, accumulate at high levels in the junctions between GSCs and cap cells, one of the niche components. Removal of these proteins from GSCs results in stem cell loss. Furthermore, DE-cadherin is required for recruiting GSCs to their niche. Our study demonstrates that anchorage of GSCs in their niche by DE-cadherin-mediated adhesion is important for stem cell maintenance and function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available