Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 445, Issue 1-2, Pages 149-150Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(02)01711-9
Keywords
DNA methylation; cerebellar granule neuron; histone deacetylase
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Funding
- NIA NIH HHS [R01-AG15347] Funding Source: Medline
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DNA methylation regulates gene expression. Neuronal 5-lipoxygenase expression increases during aging and during the proliferation of immature rat cerebellar granule neurons, In these cultures, we investigated the effects of hypomethylating agents 5-aza-2'-deoxycytidine (AdC) and valproate on 5-lipoxygenase mRNA, Both drugs increased 5-lipoxygenase mRNA in proliferating cells; only valproate was effective in differentiated neurons. We propose that neuronal 5-lipoxygenase expression can be affected by aging-altered DNA methylation and by hypomethylating drugs, such as the anticonvulsant valproate. (C) 2002 Elsevier Science B.V. All rights reserved.
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