Journal
TETRAHEDRON LETTERS
Volume 43, Issue 24, Pages 4403-4405Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)00805-5
Keywords
polyamines; DNA; RNA; affinities
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The polyamines known until today generally bind better to double-stranded RNA than to DNA, as shown in significantly higher melting point increases with RNA. We report that large and bulky polyamines with three or four positively charged nitrogen centers connected via flexible or rigid linkers to either a benzene or an adamantane core show high affinities and are large enough to exhibit a strong preference for double-stranded DNA (polydApolvdT) in comparison to RNA (polyApolyU), which differs by its smaller and deeper groove. (C) 2002 Elsevier Science Ltd. All rights reserved.
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