Journal
BIOCHEMISTRY
Volume 41, Issue 23, Pages 7318-7324Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi025507w
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Funding
- NEI NIH HHS [EY 03328] Funding Source: Medline
- NIGMS NIH HHS [R01 GM 34548] Funding Source: Medline
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The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin H. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha.
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