Journal
ORGANIC LETTERS
Volume 4, Issue 12, Pages 2029-2031Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol025859v
Keywords
-
Categories
Funding
- NCRR NIH HHS [S10-RR13673] Funding Source: Medline
- NIGMS NIH HHS [GM60003] Funding Source: Medline
- FDA HHS [BM59384] Funding Source: Medline
Ask authors/readers for more resources
[GRAPHIC] A short and efficient synthesis of 2,5,6-trisubstituted piperidines was achieved by a combination of an aza-Achmatowicz oxidation of a furyl benzenesulfonamide, conjugate addition to the resulting 2H-pyridinone, and subsequent addition of various nucleophiles to a transient N-sulfonyliminium ion. The steric bulk of the tosyl group directs attack of the nucleophile from its opposite side, thereby leading to the formation of cis-substituted products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available