Journal
SCIENCE
Volume 296, Issue 5575, Pages 2049-2052Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1071111
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Funding
- FIC NIH HHS [FO6 TW02290] Funding Source: Medline
- NCRR NIH HHS [RR09754] Funding Source: Medline
- NINDS NIH HHS [NS 34994, NS 43157] Funding Source: Medline
- PHS HHS [N0T 43994] Funding Source: Medline
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The behavior of immature cortical networks in vivo remains largely unknown. Using multisite extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred spontaneously in the hippocampus of freely moving and anesthetized rat pups. The influence of slow rhythms (0.33 and 0.1 hertz) and the contribution of both gamma-aminobutyric acid A-mediated and glutamate receptor-mediated synaptic signals in the generation of hippocampal bursts was reminiscent of giant depolarizing potentials observed in vitro. This earliest pattern, which diversifies during the second postnatal week, could provide correlated activity for immature neurons and may underlie activity-dependent maturation of the hippocampal network.
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