Journal
BRAIN RESEARCH
Volume 940, Issue 1-2, Pages 102-104Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)02586-6
Keywords
neurodegeneration; neuroinflammation; ischemia; endothelium; astrocyte
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Funding
- NHLBI NIH HHS [2R01 HL51614] Funding Source: Medline
- NINDS NIH HHS [R01 NS38195] Funding Source: Medline
- PHS HHS [R01-43284] Funding Source: Medline
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Two brain-specific proteins, S-100beta and neuron-specific enolase (NSE), are released systemically after cerebral lesions, but S-100beta levels sometimes rise in the absence of neuronal damage. We hypothesized that S-100beta is a marker of blood-brain barrier (BBB) leakage rather than of neuronal damage. We measured both proteins in the plasma of patients undergoing iatrogenic BBB disruption with mannitol, followed by chemotherapy. Serum S-100beta increased significantly after mannitol infusion (P<0.05) while NSE did not. This suggests that S-100beta is an early marker of BBB opening that is not necessarily related to neuronal damage. (C) 2002 Published by Elsevier Science B.V.
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