Journal
TETRAHEDRON LETTERS
Volume 43, Issue 25, Pages 4519-4521Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)00812-2
Keywords
microbial transformations; artemisinin; Cunninghamella echinulata; Aspergillus niger
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Microbial transformations of artemisinin 1 by Cunninghamella echinulata (AS 3.3400) and Aspergillus niger (AS 3.795) were carried out. Two products, 10beta-hydroxyartemisinin 2 and 3alpha-hydroxydeoxyartemisinin 3, were obtained. Their structures were identified on the basis of chemical and spectroscopic data. 10beta-Hydroxyartemisinin is a new compound. (C) 2002 Elsevier Science Ltd. All rights reserved.
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