Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 195, Issue 12, Pages 1647-1652Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20020408
Keywords
B cell survival; B cell receptor; signal transduction; I kappa B kinase complex; Btk
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Activation of the nuclear factor (NF)-kappaB transcription complex by signals derived from the expressed B cell antigen receptor controls B cell development, survival, and antigenic response,,. Activation of NF-kappaB is critically dependent on serine phosphorylation of the IkappaB protein by the multi-component IkappaB kinase (IKK) containing two catalytic subunits (IKKalpha and IKKbeta) and one regulatory subunit (IKKgamma). Using mice deficient for protein kinase C beta (PKCbeta) we show, an essential role of PKCbeta in the phosphorylation of IKKa and the subsequent activation of NF-kappaB in B cells. Defective IKKalpha phosphorylation correlates with impaired B cell antigetin receptor-mediated induction of the pro-survival protein Bcl-xL. Lack of IKKalpha phosphorylation and defective NF-kappaB induction in the absence of PKCbeta explains the similarity in immunodeficiencies caused by PKCbeta or IKKalpha ablation in B cells. Furthermore, the well established functional cooperation between the protein tyrosine kinase Bruton's tyrosine kinase (Btk), which regulates the activity of NF-kappaB and PKCbeta, suggests PKCbeta as a likely serine/threonine kinase component of the Btk-dependent NF-kappaB activating signal transduction chain downstream of the BCR.
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