Journal
BRITISH JOURNAL OF CANCER
Volume 86, Issue 12, Pages 1951-1956Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6600356
Keywords
N-(4-hydroxyphenyl)retinamide; apoptosis; reactive oxygen species; mitochondria; cardiolipin peroxidation; cytochrome c
Categories
Ask authors/readers for more resources
We have studied the effect of N-(4-hydroxyphenyl)retinamide on either malignant human leukaemia cells or normal cells and investigated its mechanism of action. We demonstrate that 4HPR induces reactive oxygen species increase on mitochondria at a target between mitochondrial respiratory chain complex I and II. Such oxidative stress causes cardiolipin peroxidation which in turn allows cytochrome c release to cytosol, caspase-3 activation and therefore apoptotic consumption. Moreover, this apoptotic pathway seems to be bcl-2/bax independent and count only on malignant cells but not normal nor activated lymphocytes. (C) 2002 Cancer Research UK.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available