Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 240, Issue 1-2, Pages 95-102Publisher
ELSEVIER
DOI: 10.1016/S0378-5173(02)00129-1
Keywords
liposome; charged lipids; polyethylene glycol; zeta-potential; circulation time
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Funding
- NHLBI NIH HHS [HL55519] Funding Source: Medline
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The purpose of our work was to compare the biodistribution of liposomes with different surface properties. Phosphatidylcholine (PC)/cholesterol (Chol) liposomes were prepared containing 6% mol of a charged lipid (stearylamine, SA; phosphatidic acid. PA: or phosphatidyl serine. PS) and/or polyethylene glycol (PEG)-PE of different MW (750 and 5000). zeta-Potentials and liposome clearance in mice were investigated. In vitro. the attachment of PEG in a similar fashion neutralizes the effect of,my charged component. In vivo, the chemical nature of a charged lipid becomes important. Both short PEG750 and longer PEG5000 inhibit the clearance of positively charged SA-liposomes, while only longer PEG5000 inhibits the clearance of negatively charged PA-liposomes and none of the PEGs inhibit the clearance of negatively charged PS-liposomes. The opsonins with different molecular size may be involved in the clearance of liposomes containing different charged lipids. (C) 2002 Elsevier Science B.V. All rights reserved.
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