Journal
VACCINE
Volume 20, Issue 21-22, Pages 2808-2815Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(02)00209-8
Keywords
adjuvant; QS-21; structure/function; DS-1; GPI-0100
Categories
Ask authors/readers for more resources
QS-21 is a natural saponin adjuvant derived from the tree Quillaia saponaria Molina. Previous studies over a limited dose range suggested the acylation is critical to adjuvant activity. In this study, we prepared DS-1 (deacylated QS-21) and RDS-1 (reacylated DS-1 with dodecylamine at a different site than QS-21) to determine the effect on a dose-response curve over a wider range in mice. DS-1 and RDS-1 induced IgG1 responses at higher doses compared to that induced by QS-21. DS-1 was inactive for inducing IgG2a or CTL responses at any doses. RDS-1 showed moderate IgG2a response at 240 mug, but did not show CTL response at any dose evaluated. (C) 2002 Elsevier Science Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available