Journal
SCIENCE
Volume 296, Issue 5576, Pages 2229-2232Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1070784
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- NIGMS NIH HHS [GM58213] Funding Source: Medline
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Bacterial-fungal interactions have great environmental, medical, and economic importance, yet few have been well characterized at the molecular level. Here, we describe a pathogenic interaction between Pseudomonas aeruginosa and Candida albicans, two opportunistic pathogens. P. aeruginosa forms a dense biofilm on C. albicans laments and kills the fungus. In contrast, P. aeruginosa neither binds to nor kills yeast-form C. albicans. Several P. aeruginosa virulence factors that are important in disease are involved in the killing of C. albicans laments. We propose that many virulence factors studied in the context of human infection may also have a role in bacterial-fungal interactions.
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