Journal
JOURNAL OF CELL BIOLOGY
Volume 157, Issue 7, Pages 1257-1265Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200202067
Keywords
prostate; stem cells; slow-cycling cells; branching morphogenesis; prostate regeneration
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Funding
- NIDDK NIH HHS [DK52206, P01 DK052206, DK57269, DK52634, R01 DK057269, R01 DK052644-04, R01 DK052634] Funding Source: Medline
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Stem cells are believed to regulate normal prostatic homeostasis and to play a role in the etiology of prostate cancer and benign prostatic hyperplasia. We show here that the proximal region of mouse prostatic ducts is enriched in a subpopulation of epithelial cells that exhibit three important attributes of epithelial stem cells: they are slow cycling, possess a high in vitro proliferative potential, and can reconstitute highly branched glandular ductal structures in collagen gels. We propose a model of prostatic homeostasis in which mouse prostatic epithelial stem cells are concentrated in the proximal region of prostatic ducts while the transit-amplifying cells occupy the distal region of the ducts. This model can account for many biological differences between cells of the proximal and distal regions, and has implications for prostatic disease formation.
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