Journal
GENE
Volume 293, Issue 1-2, Pages 59-65Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1119(02)00694-7
Keywords
nervous system; development; genetics
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We report the cloning and initial characterization of a novel gene encoding the Disco interacting protein 2 (Dip2). dip2 DNA complementary to RNA (cDNA) showed a high degree of sequence similarity to cDNAs of unknown function previously identified in humans and Caenorhabditis elegans. We have cloned the mouse homolog of the dip2 cDNA and characterized the expression of this gene by Northern blotting analysis and in situ hybridization to whole mount embryos. Our observations demonstrate that there is a remarkable degree of sequence conservation at the dip2 locus that is reflected in the nervous system-specific expression of both the Drosophila and mouse homologs. (C) 2002 Elsevier Science B.V. All rights reserved.
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