Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 7, Issue 3, Pages 486-492Publisher
SPIE-INT SOCIETY OPTICAL ENGINEERING
DOI: 10.1117/1.1481900
Keywords
optical imaging; photon migration; time of flight; differential absorption
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The mean time spent by photons inside a nonlocalized optically abnormal embedded inclusion has been derived analytically. The accuracy of the results has been tested against Monte Carlo and experimental data. We show that for quantification of the absorption coefficient of absorptive inclusions, a corrective factor that takes into account the size of the inclusion is needed. This finding suggests that perturbation methods derived for very small inclusions which are used in inverse algorithms require a corrective factor to adequately quantify the differential absorption coefficient of nonlocalized targets embedded in optically turbid media. (C) 2002 Society of Photo-Optical Instrumentation Engineers.
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