Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 6, Issue 4, Pages 525-532Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op020013s
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The whole-cell fermentation of aromatic coumpounds with Escherichia coli JM109 (pDTG601) on a medium scale (10-15 L) produces enantiopure cyclohexadienediols. A detailed procedure for the fermentation is described, and yields for several metabolites are provided. A similar procedure using E. coli JM109 (pDTG602) affords catechols. The dienediols are useful for asymmetric synthesis, and several important targets originating from these metabolites are tabulated.
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