Journal
INFECTION AND IMMUNITY
Volume 70, Issue 7, Pages 3965-3968Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.7.3965-3968.2002
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Funding
- NHLBI NIH HHS [HL51967] Funding Source: Medline
- NIDA NIH HHS [DA05874, F31 DA005874] Funding Source: Medline
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Resistance to reactive oxygen intermediates and reactive nitrogen intermediates in vitro of a clinical isolate of Mycobacterium tuberculosis (CDC1551) that caused a large outbreak of tuberculosis was compared to that of M. tuberculosis strains CB3.3, H37Rv, H37Ra, Erdman, RJ2E, C.C. 13, and C.C. 22 as well as M. bovis strains Ravenel and BCG. CDC1551 and CB3.3 were significantly more resistant to both hydrogen peroxide (H2O2) and acidified sodium nitrite than were the other strains tested. This biological phenotype may serve as an in vitro marker for clinical strains of M. tuberculosis likely to cause a large outbreak of tuberculosis.
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