Journal
DEVELOPMENTAL CELL
Volume 3, Issue 1, Pages 39-49Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(02)00190-9
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM53204] Funding Source: Medline
Ask authors/readers for more resources
When preadipocytes reenter the cell cycle, PPARgamma expression is induced, coincident with an increase in DNA synthesis, suggesting the involvement of the E2F family of cell cycle regulators. We show here that E2F1 induces PPAR transcription during clonal expansion, whereas E2F4 represses PPARgamma expression during terminal adipocyte differentiation. Using a combination of in vivo experiments with knockout and chimeric animals and in vitro experiments, we demonstrate that the absence of E2F1 impairs, whereas depletion of E2F4 stimulates, adipogenesis. E2Fs hence represent the link between proliferative signaling pathways, triggering clonal expansion, and terminal adipocyte differentiation through regulation of PPARgamma expression. This underscores the complex role of the E2F protein family in the control of both cell proliferation and differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available