Journal
JOURNAL OF BACTERIOLOGY
Volume 184, Issue 14, Pages 4025-4032Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.184.14.4025-4032.2002
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We used microarrays and real-time reverse transcription-PCR to analyze the global transcriptional response of Mycobacterium tuberculosis to low pH in vitro, which may mimic an environmental signal encountered by phagocytosed mycobacteria. Eighty-one genes were differentially expressed > 1.5-fold, including many involved in fatty acid metabolism. The most highly induced genes showed homology with nonribosomal peptide synthetases/polyketide synthases.
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