Journal
CEREBRAL CORTEX
Volume 12, Issue 7, Pages 702-709Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/12.7.702
Keywords
-
Categories
Funding
- NIDA NIH HHS [DA12462] Funding Source: Medline
- NIMH NIH HHS [MH01620, MH49428, MH51561, MH51864, MH01046] Funding Source: Medline
Ask authors/readers for more resources
Recent studies in rodents have suggested that some cortical GABAergic interneurons arise within the neuroepithelium of the subcortical telencephalon then migrate dorsally into the cerebral cortex. These studies have relied heavily on short-term organotypic culture methods and on the analysis of mutant mice that die during the neonatal period. The purpose of this study is to ascertain directly whether cells labeled in the subcortical telencephalon in vivo differentiate into mature cortical interneurons and whether any cortical interneurons arise from the dorsal, cortical neuroepithelium. Mitotic cells within the neonatal cortex or subcortical telencephalon were labeled by focal injections of [H-3]thymidine into the brains of neonatal ferrets. The fates of labeled cells were assessed in mature animals 6 weeks later. Our results suggest that many cortical interneurons, but not cortical projection neurons, derive from the subcortical telencephalon. Conversely, cortical projection neurons, but few if any interneurons, are generated within the proliferative zones of the neocortex.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available