Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 13, Pages 6841-6844Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.13.6841-6844.2002
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Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
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