Journal
INFECTION AND IMMUNITY
Volume 70, Issue 7, Pages 3969-3972Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.7.3969-3972.2002
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Alveolar and cystic hydatidosis are caused by infection with the larval stages of Echinococcus multilocularis and Echinococcus granulosus, respectively. A host-protective antigen has been identified in E. granulosus. Here we identify the presence of a closely related protein in E. multilocularis, characterize and express a cDNA encoding the antigen (designated EM95), determine the structure of the em95 gene, and demonstrate that the EM95 recombinant protein can be used to induce significant levels of protection against challenge infection with E. multilocularis eggs in mice.
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