Journal
EMERGING INFECTIOUS DISEASES
Volume 8, Issue 7, Pages 657-661Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid0807.010277
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Funding
- FIC NIH HHS [TW01133, D43 TW001133] Funding Source: Medline
- NIAID NIH HHS [U19 AI045452, U01 AI045452, AI45452] Funding Source: Medline
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We isolated Andes virus (formal name: Andes virus [ANDV], a species in the genus Hantavirus), from serum of an asymptomatic 10-year-old Chilean boy who died 6 days later of hantavirus pulmonary syndrome (HIPS). The serum was obtained 12 days after his grandmother died from HPS and 2 days before he became febrile. No hantavirus immunoglobulin (Ig) G or IgM antibodies were detected in the serum sample. After three blind passages, ANDV antigens were detected in Vero E6 cells by immunofluorescence assay and enzyme-linked immunosorbent assay, and ANDV RNA was detected by reverse transcription-polymerise chain reaction. A fragment of the virus genome showed 96.2% nucleotide identity with that of prototype ANDV. To our knowledge, this is the first isolation of any agent of hemorrhagic fever with HIPS from a human and the first such isolation of hantavirus before symptoms of that syndrome or HPS began.
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