Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 66, Issue 7, Pages 1610-1614Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.66.1610
Keywords
lentinan; Lentinas edodes; Agaricus blazei polysaccharides; cytochrome P450; tumor necrosis factor-alpha (TNF-alpha)
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To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.
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