Journal
JOURNAL OF LIPID RESEARCH
Volume 43, Issue 7, Pages 1125-1132Publisher
ELSEVIER
DOI: 10.1194/jlr.M200060-JLR200
Keywords
fatty acids; hypolipidemic drugs; electrospray ionization tandem mass spectrometry; hepatocyte nuclear factor-4 alpha
Categories
Ask authors/readers for more resources
The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs. Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs. Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available