Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 7, Issue 3, Pages 321-328Publisher
SPIE-INT SOCIETY OPTICAL ENGINEERING
DOI: 10.1117/1.1484163
Keywords
diabetes; aqueous humor; birefringence; motion artifact; glucose; polarimetry
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Over the last two decades polarimetry has been investigated as a noninvasive alternative for glucose monitoring in support of diabetic patients. In particular, the anterior chamber of the eye containing the fluid known as the aqueous humor has been confirmed to be the optimal sensing site for polarimetric glucose measurements due to its reasonable pathlength (1 cm), low scatter, and minimal depolarization index. In essence, the eye can be thought of as an optical window into the body. In this paper, we will first introduce the key challenges that must be overcome to make the use of polarized light in the eye a viable method for noninvasive glucose monitoring, summarize our work toward this endeavor, and then report on our latest research, namely, the effect of temperature, pH, and corneal birefringence on our polarimetric glucose monitoring system. (C) 2002 Society of Photo-Optical Instrumentation Engineers.
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