Journal
FRONTIERS IN NEUROENDOCRINOLOGY
Volume 23, Issue 3, Pages 257-291Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0091-3022(02)00003-1
Keywords
neuroendocrine; development; hypothalamus; birthdating; corticotropin-releasing hormone; thyrotropin-releasing hormone; somatostatin; dopamine; growth hormone-releasing hormone; paraventricular nucleus
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Funding
- NIMH NIH HHS [F31 MH010623-01] Funding Source: Medline
- NINDS NIH HHS [R01 NS016686, R37 NS016686] Funding Source: Medline
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The development of the neuroendocrine hypothalamus has been studied using a variety of neuroanatomical and molecular techniques. Here, the major findings that mold our understanding of hypothalamic development are reviewed. The rat hypothalamus is generated predominantly from the third ventricular neuroepithelium in a lateral early to medial late pattern dictated perhaps by the medially receding third ventricle. Neuroendocrine neurons seem to exhibit a delayed migrational strategy, showing relatively early birthdates, although they are located in the latest-generated, periventricular nuclei. Several homeobox genes seem to play a role in hypothalamic development, and gene knockout experiments implicate a number of genes of importance in the generation of the neuroendocrine cell type. (C) 2002 Elsevier Science (USA). All rights reserved.
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