Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 23, Issue 7, Pages 299-302Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(02)02060-6
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Transport of cystine across the cell membrane is essential for synthesis of the major cellular aintioxidant glutathione. Cystine uptake in the brain occurs by both the Na+-independent x(c)(-) cystine-glutamate exchanger and the X-AG(-) family of high-affinity, Na+-dependent glutamate transporters. New evidence concerning the role of cystine transport in the defence against oxidative stress is described.
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