Journal
ATHEROSCLEROSIS
Volume 237, Issue 1, Pages 208-219Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2014.09.001
Keywords
Reactive oxygen species; Oxidative stress; Nitric oxide; Atherosclerosis
Funding
- DFG [LI-1042/1-1, Do1289/6-1]
- BMBF [01EO1003]
- Johannes Gutenberg University Medical Center Mainz (CTVB)
- U.S. Department of Defense [W81XWH-12-2-0091]
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In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide synthase (eNOS) and the mitochondrial electron transport chain. On the other hand, the vasculature is protected by antioxidant enzyme systems, including superoxide dismutases, catalase, glutathione peroxidases and paraoxonases, which detoxify ROS. Cardiovascular risk factors such as hypercholesterolemia, hypertension, and diabetes mellitus enhance ROS generation, resulting in oxidative stress. This leads to oxidative modification of lipoproteins and phospholipids, mechanisms that contribute to atherogenesis. In addition, oxidation of tetrahydrobiopterin may cause eNOS uncoupling and thus potentiation of oxidative stress and reduction of eNOS-derived NO, which is a protective principle in the vasculature. This review summarizes the latest advances in the role of ROS-producing enzymes, antioxidative enzymes as well as NO synthases in the initiation and development of atherosclerosis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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