Journal
PARASITE IMMUNOLOGY
Volume 24, Issue 7, Pages 391-393Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-3024.2002.00470.x
Keywords
severe malaria; helminths; gametocytes; incidence; CD23; nitric oxide; ecology
Categories
Ask authors/readers for more resources
The burden of malaria mortality has been a major evolutionary influence on human immunity. The selection of the most successful immune responses against malaria has been in populations concomitantly infected by intestinal helminths. Animal models have shown that coinfections with helminths and protozoa in the same host elicit a range of antagonist and synergistic interactions. Recent findings suggest similar interactions take place between helminths, Plasmodium falciparum and humans. However, as the threat of HIV and tuberculosis becomes a major selective force, what used to be a successful ecological system may now prove detrimental. Nevertheless, the understanding of the ecological forces at play may expose new intervention targets for malaria control, and give a new perspective on our shortcomings against the deadliest of human parasites.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available