Journal
ATHEROSCLEROSIS
Volume 226, Issue 1, Pages 291-295Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2012.11.004
Keywords
Polycystic ovary syndrome; Epicardial fat thickness; Carotid intima-media thickness; Insulin resistance; Cardiovascular disease risk
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Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting reproductive-age women and is reported to be associated with an increased risk of cardiovascular disease and early atherosclerosis. Epicardial fat thickness (EF) is clinically related to subclinical atherosclerosis and visceral fat changes. Therefore, the objective of this study is to compare the carotid artery intima-media thickness (CIMT), EF and cardiometabolic risk factors in patients with PCOS, patients with idiopathic hirsutism (IH) and healthy controls. Methods: This cross-sectional controlled study was conducted in a training and research hospital. The study population consisted of 50 reproductive-age PCOS women, 34 women with IH and 39 control subjects. We evaluated anthropometric, hormonal and metabolic parameters as well as CIMT and EF measurements in PCOS patients, IH patients and controls. Results: The mean fasting insulin, HOMA-IR, hsCRP, GGT, CIMT, and EF levels were significantly higher in patients with PCOS and IH (p < 0.05). A significant positive correlation was found between EF and age, BMI, WHR, Ferriman Gallwey score (FG), fasting insulin, HOMA-IR, triglyceride, total cholesterol, LDL-C, 17 OH progesterone, free testosterone, CIMT, hsCRP, and GGT, whereas a significant negative correlation was observed between EF and HDL-C (p < 0.05). In the multiple linear regression analyses, EF was found to be associated with the FG (beta coefficient: 0.389, p < 0.001), CIMT (beta coefficient: 0.376, p < 0.001) and free testosterone levels (beta coefficient: 0.173, p < 0.038). Conclusion: EF appears to be a marker that will enable the detection of the cardiometabolic response in patients with PCOS and IH, even at an early stage. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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