Journal
ATHEROSCLEROSIS
Volume 228, Issue 1, Pages 211-216Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2013.01.004
Keywords
Cathepsin K; Coronary artery disease; Atherosclerotic plaque; Biomarker; Extracellular matrix protein degradation
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [21590952, 20249045]
- Japan Nakatomi Foundation [26007578]
- National Natural Science Foundation of China [30960128, 81260068]
- Ministry of Education, Science and Technology of Korea [2010-0019913]
- Grants-in-Aid for Scientific Research [21590952, 24659385] Funding Source: KAKEN
- National Research Foundation of Korea [2010-0019913] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Background: Cathepsin K (CatK) is one of the most potent mammalian collagenases involved in atherosclerosis-based vascular disease. We investigated whether circulating CatK is associated with the prevalence of coronary artery disease (CAD). Methods: Two-hundred fifty-two consecutive subjects were enrolled from among patients who underwent coronary angiography and intravascular ultrasound analyses. One-hundred thirty-two age-matched subjects served as controls. Plasma CatK, intact procollagen type I N-terminal propeptide (I-PINP), and linked carboxy-terminal telopeptide of collagen type I (ICTP) were measured. Results: Patients with CAD had higher CatK levels (44.0 +/- 31.2 versus 15.5 +/- 8.3 ng/mL, P < 0.001) and ICTP/I-PINP ratios (0.2 +/- 0.1 versus 0.04 +/- 0.03, P < 0.001) than the controls. Patients with acute coronary syndrome had higher CatK levels than those with stable angina pectoris. Overall, linear regression analysis showed that the CatK levels correlated positively with ICTP/I-PINP ratios (r = 0.41, P < 0.001). Multiple logistic regression analysis showed that CatK levels were independent predictors of CAD (odds ratio, 1.15; 95% CI, 1.07 to 1.23; P < 0.01). Furthermore, CatK levels were also correlated positively with percent plaque volumes and inversely with percent fibrous volumes by intravascular ultrasound. Conclusions: These data indicated that high levels of CatK are closely linked with the presence of CAD and that CatK serves as a novel biomarker for CAD. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available