Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 118, Issue 1, Pages 140-143Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2002.03650.x
Keywords
acute leukaemia; complete remission; adult; unrelated; cord blood transplantation
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We performed a clinical comparison of unrelated cord blood transplantation (UCBT) and unrelated bone marrow transplantation in adult acute leukaemia patients in complete remission (CR) who received the same conditioning regimen, graft-versus-host disease (GvHD) prophylaxis and supportive treatment. The incidence of acute GvHD was almost the same between the two groups, but the haematopoietic recovery was delayed and the incidence of chronic GvHD was higher in the UCBT group. The probability of 2 year disease-free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT.
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