Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 196, Issue 1, Pages 65-75Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20020201
Keywords
chemokine; high endothelial venule; adhesion; lymphoid organ; B cell
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Funding
- NIAID NIH HHS [AI45073, R01 AI045073] Funding Source: Medline
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B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we show that the homing of CXCR4(-/-) B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. We also find that CXCR4 can contribute to T cell homing. Using intravital microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 and CXCR4 are predesensitized. In Peyer's patches, B cell entry is dependent on CXCR5 in addition to CCR7/CXCR4. CXCL12 (SDF1) is displayed broadly on HEVs, whereas CXCL13 (BLC) is found selectively on Peyer's patch follicular HEVs. These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches.
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