Journal
BIOLOGICAL CHEMISTRY
Volume 383, Issue 7-8, Pages 1133-1138Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2002.123
Keywords
autoimmune diseases; CD26; dipeptidyl peptidase IV; T cell activation
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Activated T lymphocytes express high levels of dipeptidyl peptidase IV (DP IV)/CD26. Recent studies support the notion that DP IV may play an important role in the regulation of differentiation and growth of T lymphocytes. This article gives a short overview on DP IV/CD26 expression and effects on immune cells in vitro and in vivo. A major focus of this review are clinical aspects of the function of CD26 on hematopoietic cells and the potential usage of synthetic DP IV inhibitors as therapeutics in inflammatory disorders.
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