Journal
ATHEROSCLEROSIS
Volume 222, Issue 2, Pages 314-323Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2012.01.020
Keywords
miR-27; Inflammation; Lipid metabolism; Mystery; Atherosclerosis
Funding
- National Natural Sciences Foundation of China [81170278, 81101213, 81070220]
- Hunan Provincial Natural Sciences Foundation of China [10JJ9019]
- Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Province, China [2008-244]
- Science and Technology Department of Heng Yang of Hunan Province [2010kj17]
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Atherosclerosis (As) is now widely appreciated to represent a chronic inflammatory reaction of the vascular wall in response to dyslipidemia and endothelial distress involving the inflammatory recruitment of leukocytes and the activation of resident vascular cells. MicroRNAs (miRNAs) are a group of endogenous, small (similar to 22 nucleotides in length) non-coding RNA molecules, which function specifically by base pairing with mRNA of genes, thereby induce translation repressions of the genes within metazoan cells. Recently, the function of miR-27, one of the miRNAs, in the initiation and progression of atherosclerosis has been identified. In vivo and in vitro studies suggest that miR-27 may serve as a diagnostic and prognostic marker for atherosclerosis. More recently, studies have identified important roles for miR-27 in angiogenesis, adipogenesis, inflammation, lipid metabolism, oxidative stress, insulin resistance and type 2 diabetes, etc. In this review, we focus on the role of miR-27 in the development of vulnerable atherosclerotic plaques, potential as a disease biomarker and novel therapeutic target in atherosclerosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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