Journal
IMMUNITY
Volume 17, Issue 1, Pages 51-62Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(02)00335-7
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Funding
- NIAID NIH HHS [AI43576] Funding Source: Medline
- NIGMS NIH HHS [GM29361] Funding Source: Medline
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Blimp-1, a transcriptional repressor, drives the terminal differentiation of B cells to plasma cells. Using DNA microarrays, we found that introduction of Blimp-1 into B cells blocked expression of a remarkably large set of genes, while a much smaller number was induced. Blimp-1 initiated this cascade of gene expression changes by directly repressing genes encoding several transcription factors, including Spi-B and Id3, that regulate signaling by the B cell receptor. Blimp-1 also inhibited immunoglobulin class switching by blocking expression of AID, Ku70, Ku86, DNA-PKcs, and STAT6. These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.
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