Journal
ATHEROSCLEROSIS
Volume 219, Issue 2, Pages 880-886Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2011.09.010
Keywords
HDL subspecies; Macronutrient composition; 3-Day food records; Omega-3 fatty acids; Monozygotic twins
Funding
- Doctoral Programs of Public Health
- Helsinki University Central Hospital
- Research Foundation of the University of Helsinki
- Novo Nordisk Foundation
- Jalmari Rauha Ahokas
- Biomedicum Helsinki
- Finnish Foundation for Cardiovascular Research
- Gyllenberg Foundation
- Yrjo Jahnsson Foundation
- Juho Vainio Foundation
- National Institute on Alcohol Abuse and Alcoholism [AA-08315, AA-00145, AA-12502]
- Academy of Finland [44069, 100499, 201461]
- Academy of Finland Centre of Excellence in Complex Disease Genetics
- Sapienza University Rome
- Academy of Finland (AKA) [201461, 201461] Funding Source: Academy of Finland (AKA)
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Background: Studies on diet and high-density lipoprotein (HDL) subspecies distribution are limited. Objective: We examined the relationship between macronutrient composition and lipoprotein particle size and HDL subspecies independent of genetic effects by studying monozygotic (MZ) twins. Methods: 24 healthy MZ twin pairs aged 23-33 years were identified from two longitudinal population-based studies, FinnTwin16 and FinnTwin12. Total energy and nutrient intake were assessed with 3-day food records and physical activity was measured by the Baecke index. HDL subspecies distribution was determined by non-denaturing gradient gel electrophoresis. Associations between diet composition and HDL mean particle size were determined by multivariate nutrient density models adjusted for confounding variables. Results: Substituting one energy percentage from omega-3 polyunsaturated fatty acids (n-3 PUFAs) for a corresponding amount of energy from other type of fats was related to changes in the relative proportions of the HDL subspecies 2b, 3a and 3b toward a larger mean particle size in men (beta +/- SE: 1.00 +/- 0.26 nm, p = 0.004) and women (beta +/- SE: 0.90 +/- 0.21 nm, p = 0.001). This association remained significant in analyses controlling for genetic and shared environmental influences using within-pair differences of the measures in MZ twin pairs (beta +/- SE: 0.37 +/- 0.14 nm, p = 0.019). Twins with the higher n-3 PUFA intake had significantly higher proportions of large HDL2b particles and lower proportions of smaller-sized HDL3a and HDL3b particles as compared to their co-twins with lower intakes (p < 0.05). Conclusions: Our data suggest that n-3 PUFA intake is associated with a favorable change in the distribution of HDL subspecies towards larger particles independent of genetic and shared environmental factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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