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AMERICAN JOURNAL OF OPHTHALMOLOGY
Volume 134, Issue 1, Pages 41-46Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0002-9394(02)01527-1
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PURPOSE: To determine the effect of long term intern mittent trimethoprim/sulfamethoxazole treatment on re currences of toxoplasmic retinochoroiditis. DESIGN: Prospective randomized open-labeled inter, ventional clinical trial. METHODS: A total of 124 patients with a history of recurrent toxoplasmic retinochoroiditis were randomized to treatment with one tablet of trimethoprim (160 mg)/ sulfamethoxazole (800 mg) (Bactrim F; Roche Pharmaceuticals, Ric de Janeiro, Brazil) every 3 days (61 patients) or to observation without treatment (63 patients) and were followed monthly for up to 20 consecutive months for clinical signs of disease recurrence. A recurrence was defined as a new focus of necrotizing retinochoroiditis with active inflammation either adjacent to or remote from preexisting retinochoroidal scars. RESULTS: Recurrences developed in four (6.6%) treated patients and in 15 (23.8%) controls (P = .01). Treatment was discontinued prematurely in four patients because of mild drug reactions. CONCLUSION: Long-term intermittent treatment with trimethoprim/sulfamethoxazole can reduce the rate of recurrent toxoplasmic retinochoroiditis. (C) 2002 by Elsevier Science Inc. All rights reserved.
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