Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 161, Issue 1, Pages 13-17Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0002-9440(10)64151-X
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Funding
- NIAMS NIH HHS [AR02594, R01 AR002594] Funding Source: Medline
- NIA NIH HHS [AG20197, P01 AG017617, R01 AG015408, AG15408, R01 AG020197, AG17617, AG05891, R37 AG005891] Funding Source: Medline
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The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a potentially large population being at risk to develop this prionosis. None of the prionoses currently have an effective treatment. Recently, vaccination has been shown to be effective in mouse models of another neurodegenerative condition, namely Alzheimer's disease. Here we report that vaccination with recombinant mouse prion protein delays the onset of prion disease in mice. Vaccination was performed both before peripheral prion exposure and after exposure. A delay in disease onset was seen in both groups, but was more prolonged in animals immunized before exposure. The increase in the incubation period closely correlated with the anti-prion protein antibody titer. This promising finding suggests that a similar approach may work in humans or other mammalian species at risk for prion disease.
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