Screening of the topical anti-inflammatory activity of some Central American plants

Hexane, chloroform and methanol extracts of seven herbal drugs used in the folk medicine of Central America against skin disorders (Aristolochia trilobata leaves and bark, Bursera simaruba bark, Hamelia patens leaves, Piper amalago leaves, and Syngonium podophyllum leaves and bark) were evaluated for their topical anti-inflammatory activity against the Croton oil-induced ear oedema in mice. Most of the extracts induced a dose-dependent oedema reduction. The chloroform extract of almost all the drugs exhibited interesting activities with ID50 values ranging between 108 and 498 mug/cm(2), comparable to that of indomethacin (93 mug/cm(2)). Therefore, the tested plants are promising sources of principles with high anti-inflammatory activity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.