Journal
ARCHIVES OF MEDICAL RESEARCH
Volume 33, Issue 4, Pages 379-388Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0188-4409(02)00373-9
Keywords
Aedes aegypti; flavivirus; vector competence; population genetics.
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Funding
- FIC NIH HHS [D43 TW01130] Funding Source: Medline
- NIAID NIH HHS [U01AI45430, R01-AI49256] Funding Source: Medline
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Aedes aegypti is the primary vector of yellow fever (YF) and dengue fever (DF) flaviviruses worldwide. In this review we focus on past and present research on genetic components and environmental factors in Aedes aegypti that appear to control flavivirus transmission. We review genetic relationships among Ae. aegypti populations throughout the world and discuss how variation in vector competence is correlated with overall genetic differences among populations. We describe current research into how genetic and environmental factors jointly affect distribution of vector competence in natural populations. Based on this information, we propose a population genetic model for vector competence and discuss our recent progress in testing this model. We end with a discussion of approaches being taken to identify the genes that may control flavivirus susceptibility in Ae. aegypti. (C) 2002 IMSS. Published by Elsevier Science Inc.
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