Higher Fibrinogen Levels Predict Progression of Coronary Artery Calcification in Adults with Type 1 Diabetes

Aim: To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes. Methods: Data from a prospective cohort - the Coronary Artery Calcification in Type 1 Diabetes Study were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4 +/- 0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by >= 2.5 mm(3) or development of clinical coronary artery disease during the follow-up period. Results: Fibrinogen levels were higher in progressors than in non-progressors ( 276 +/- 61 mg/dl versus 259 +/- 61 mg/dl, p = 0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile. Conclusions: Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors. (c) 2010 Elsevier Ireland Ltd. All rights reserved.