Journal
BIOLOGICAL CHEMISTRY
Volume 383, Issue 7-8, Pages 1035-1044Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2002.112
Keywords
activation; apoptosis; cathepsins; granzymes; lysosomal cysteine proteases
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Apoptosis or programmed cell death is the major mechanism used by multicellular organisms to remove infected, excessive and potentially dangerous cells. Cysteine proteases from the caspase family play a crucial role in the process. However, there is increasing evidence that lysosomal proteases are also involved in apoptosis. In this review various lysosomal proteases and their potential contribution to propagation of apoptosis are discussed.
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