Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 129, Issue 1, Pages 177-182Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2249.2002.01882.x
Keywords
apoptosis; Fas; lachrymal gland; salivary gland; T cell
Categories
Ask authors/readers for more resources
The objective of our study was to investigate the possibility of Fas ligand protein abnormalities in certain types of Sjogren's syndrome patients with enlarged exocrine glands. Fas ligand expression by lymphocytes infiltrating the lachrymal glands and by peripheral blood monocytes in Sjogren's syndrome patients with enlarged exocrine glands was assessed immunohistologically and by immunoblotting. Cytotoxicity of peripheral blood monocytes and sensitivity to steroids in Sjogren's syndrome patients with enlarged exocrine glands were studied by functional assay. Minimal Fas ligand expression was detected in the lymphocytes of the lachrymal glands and a decreased level of Fas ligand was found in peripheral blood monocytes as assessed by immunoblotting. Functional assay confirmed the decreased cytotoxicity of lymphocytes in Sjogren's syndrome patients with enlarged exocrine glands, and that it is not affected by anti-Fas ligand antibody. By contrast, the sensitivity of lymphocytes in Sjogren's syndrome patients with enlarged exocrine glands to steroids was increased. These observations suggest that abnormal expression and function of Fas ligand occurs in Sjogren's syndrome patients with enlarged exocrine glands.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available