Journal
ATHEROSCLEROSIS
Volume 204, Issue 1, Pages 184-190Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2008.09.001
Keywords
Mitochondrial mutations; Quantitative assay method; Atherosclerotic lesions of intima
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A mutant allele quantitative assay was developed to study somatic mitochondrial mutations associated with human diseases. This assay may be used in the clinical diagnostics for diseases associated with somatic mutations. To detect somatic mutations associated with atherosclerotic lesions of the aortal intima, we analyzed 40 mitochondrial mutations previously identified in several pathological conditions. 10 mutations associated with lipofibrosis plaques were found in mitochondrial genes that encode rRNA 12S, tRNA-Leu (UUR recognition codon), tRNA-Leu (CUN recognition codon), subunits of 1, 2, 5, and 6 NADH-dehydrogenase, and cytochrome B. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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