Journal
ATHEROSCLEROSIS
Volume 206, Issue 2, Pages 500-504Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2009.03.012
Keywords
LIPG; Endothelial lipase; HDL; Television; Physical activity
Funding
- National Institutes of Health, National Institute on Aging [5P01AG023394-02]
- NIH/NHLBI [HL54776]
- NIH/NIDDK [DK075030]
- U.S. Department of Agriculture Research Service [53-K06-5-10, 58-1950-9-001]
- Fulbright-Spanish Ministry of Education and Science
- [T32 DK007651-19]
Ask authors/readers for more resources
Background: Plasma high density lipoprotein (HDL) cholesterol (HDL-C) concentration is highly heritable but is also modifiable by environmental factors including physical activity. HDL-C response to exercise varies among individuals, and this variability may be associated with genetic polymorphisms in the key regulators of HDL metabolism including endothelial lipase (LIPG). Methods: We examined associations between variants LIPG T111I (rs2000813) and LIPG i24582 (rs6507931), HDL and television viewing/computer use (screen time) as a marker for physical inactivity in a population with high prevalence of metabolic syndrome. Subjects consisted of 539 White men and 584 women (mean +/- S. D., 49 +/- 16 years) participating in the GOLDN study. Results: We did not observe an association with either LIPG SNP or HDL independently of screen time. In multi-adjusted linear regression models, HDL interacted significantly with screen time as a continuous variable in LIPG i24582 subjects with TT genotype (P < 0.05). By dichotomizing screen time into high and low levels, we found significant genotype-associated differences in HDL in women but not men. When screen time was >= 2.6 h/day, the concentrations of total HDL-C, large HDL, large low density lipoprotein (LDL) were lower, the concentration of small LDL was higher and HDL and LDL particle sizes were smaller in subjects with LIPG i24582 TT compared to CT and CC subjects (P < 0.05). Conclusions: We found a significant gene-physical inactivity interaction for HDL and some LDL measures for the LIPG i24582 polymorphism. Higher levels of physical activity may be protective for HDL-C concentrations and low activity detrimental in LIPG i24582 TT individuals, especially in women. (C) 2009 Published by Elsevier Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available