Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 653, Issue 1-2, Pages 279-287Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-328X(02)01263-9
Keywords
cross-coupling; Suzuki-Miyaura; Stille-Migita; stannatrane; carbapenem; pharmaceutical
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Process design and development of drug candidates using cross-coupling reactions as key steps are discussed. In the anti-MRS carbapenem project, all drug candidates were prepared effectively in a few steps from the commercially available diazo intermediate by either Suzuki-Miyaura cross-coupling or Stille-Migita cross-coupling, demonstrating the versatility, effectiveness, functional group tolerability, and mild reaction conditions of cross-coupling methods. (C) 2002 Elsevier Science B.V. All rights reserved.
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