Journal
ATHEROSCLEROSIS
Volume 202, Issue 2, Pages 321-329Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2008.06.006
Keywords
Oxidative stress; Diabetes; Cardiovascular disease; Risk; Biomarker
Funding
- Diabetes UK
- BUPA Foundation
- Novo Nordisk
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Oxidative stress is associated with many chronic diseases. In this review, we look at the role that oxidative stress may play in diabetes and related cardiovascular disease (CVD) and how oxidative damage may be measured in the plasma. Increased production of reactive oxygen species (ROS) has been implicated in the initiation and progression of both of these conditions and it may be that oxidative stress accounts for the unexplained increase in cardiovascular risk observed in diabetes. Plasma measurements are difficult because of the highly reactive nature of these molecules. Several studies have focused on measuring the total antioxidant buffering capacity of plasma or alternatively specific measures of free radical-mediated damage such as F-2-isoprostane or oxidised-LDL (Ox-LDL). Perhaps, in the future, the discovery of an 'easy to measure marker' of oxidative stress might he incorporated into risk prediction in diabetes and cardiovascular disease. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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